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Gene: Il6st (interleukin 6 signal transducer) Rattus norvegicus
Symbol: Il6st
Name: interleukin 6 signal transducer
Description: Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Localizes to neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 signal transducer); PARTICIPATES IN interleukin-6 signaling pathway; interleukin-27 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ac1055; Gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
Homo sapiens (human) : IL6ST (interleukin 6 signal transducer)  HGNC  Alliance
Mus musculus (house mouse) : Il6st (interleukin 6 signal transducer)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il6st (interleukin 6 signal transducer)
Pan paniscus (bonobo/pygmy chimpanzee) : IL6ST (interleukin 6 signal transducer)
Canis lupus familiaris (dog) : IL6ST (interleukin 6 signal transducer)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il6st (interleukin 6 signal transducer)
Sus scrofa (pig) : IL6ST (interleukin 6 signal transducer)
Chlorocebus sabaeus (African green monkey) : IL6ST (interleukin 6 signal transducer)
Heterocephalus glaber (naked mole-rat) : Il6st (interleukin 6 signal transducer)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0244,279,199 - 44,319,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,320,957 - 63,361,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,806,301 - 43,842,365 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1243,736,911 - 43,762,480 (+)NCBI
Celera239,857,022 - 39,886,283 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il6st
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2903
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.