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Gene: Ins1 (insulin 1) Rattus norvegicus
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Symbol: Ins1
Name: insulin 1
Description: Exhibits chaperone binding activity; insulin receptor binding activity; and protease binding activity. Involved in response to cAMP; response to cytokine; and response to peptide hormone. Localizes to the extracellular space and secretory granule. Colocalizes with the cytoplasm. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin); PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; autophagy pathway; INTERACTS WITH triclosan (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Insulin; insulin-1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
Celera1246,946,414 - 246,946,981 (+)NCBICelera
Cytogenetic Map1q55NCBI
RH 3.4 Map11654.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ins1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2915
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.