Gene: Ins2 (insulin 2) Rattus norvegicus
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Symbol: Ins2
Name: insulin 2
Description: Exhibits protease binding activity; predicted to be involved in several processes, including negative regulation of cellular metabolic process, positive regulation of cellular metabolic process, and positive regulation of signal transduction; localizes to the extracellular space and secretory granule; predicted to colocalize with the cytoplasm; used to study hypertension; biomarker of Alzheimer's disease; orthologous to human INS (insulin); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-peptide; CP-II; insulin-2
Orthologs:
Homo sapiens (human) : INS (insulin)  HGNC  Alliance
Mus musculus (house mouse) : Ins2 (insulin II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ins (insulin)
Pan paniscus (bonobo/pygmy chimpanzee) : INS (insulin)
Canis lupus familiaris (dog) : INS (insulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ins (insulin)
Sus scrofa (pig) : INS (insulin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ins2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2916
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.