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Gene: Itgb1 (integrin subunit beta 1) Rattus norvegicus
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Symbol: Itgb1
Name: integrin subunit beta 1
Description: Exhibits several functions, including cytoskeletal protein binding activity; enzyme binding activity; and fibronectin binding activity. Predicted to contribute to C-X3-C chemokine binding activity. Involved in several processes, including bicellular tight junction assembly; cellular response to mechanical stimulus; and regulation of neuron differentiation. Localizes to several cellular components, including focal adhesion; hemidesmosome; and integral component of plasma membrane. Predicted to colocalize with cytoplasmic vesicle; perinuclear region of cytoplasm; and ruffle membrane. Used to study hydrocephalus and myocardial infarction. Biomarker of glomerulonephritis. Orthologous to human ITGB1 (integrin subunit beta 1); PARTICIPATES IN integrin mediated signaling pathway; altered integrin mediated signaling pathway; altered Reelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-adrenaline; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta OL; beta oligodendroglia; fibronectin receptor subunit beta; Integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta-1; integrin VLA-4 subunit beta; integrin, beta 1; VLA-4 subunit beta
Orthologs:
Homo sapiens (human) : ITGB1 (integrin subunit beta 1)  HGNC  Alliance
Mus musculus (house mouse) : Itgb1 (integrin beta 1 (fibronectin receptor beta))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb1 (integrin subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB1 (integrin subunit beta 1)
Canis lupus familiaris (dog) : ITGB1 (integrin subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb1 (integrin subunit beta 1)
Sus scrofa (pig) : ITGB1 (integrin subunit beta 1)
Chlorocebus sabaeus (African green monkey) : ITGB1 (integrin subunit beta 1)
Heterocephalus glaber (naked mole-rat) : Itgb1 (integrin subunit beta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01961,677,512 - 61,725,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01972,324,582 - 72,372,325 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,600,095 - 58,647,531 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11958,605,791 - 58,652,463 (-)NCBI
Celera1956,037,604 - 56,085,651 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Itgb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2927
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.