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Gene: Itgb4 (integrin subunit beta 4) Rattus norvegicus
Symbol: Itgb4
Name: integrin subunit beta 4
Description: Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and peripheral nervous system myelin formation. Localizes to cell cortex and membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex localized type; junctional epidermolysis bullosa non-Herlitz type; and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: GP150; integrin beta 4; integrin beta-4; integrin, beta 4
Homo sapiens (human) : ITGB4 (integrin subunit beta 4)  HGNC  Alliance
Mus musculus (house mouse) : Itgb4 (integrin beta 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb4 (integrin subunit beta 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB4 (integrin subunit beta 4)
Canis lupus familiaris (dog) : ITGB4 (integrin subunit beta 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb4 (integrin subunit beta 4)
Sus scrofa (pig) : ITGB4 (integrin subunit beta 4)
Chlorocebus sabaeus (African green monkey) : ITGB4 (integrin subunit beta 4)
Heterocephalus glaber (naked mole-rat) : Itgb4 (integrin subunit beta 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010104,524,000 - 104,560,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,523,996 - 104,561,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,725,179 - 103,761,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,080,452 - 106,116,632 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110106,094,955 - 106,131,136 (+)NCBI
Celera1099,781,746 - 99,817,137 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itgb4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2928
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.