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Gene: Itpr1 (inositol 1,4,5-trisphosphate receptor, type 1) Rattus norvegicus
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Description: Exhibits several functions, including inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ion channel binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to cAMP; generation of neurons; and liver regeneration. Localizes to several cellular components, including GABA-ergic synapse; endoplasmic reticulum membrane; and sarcoplasmic reticulum. Used to study asthma. Biomarker of Huntington's disease; cardiac arrest; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor type 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 145-triphosphate receptor type 1; InsP3R; InsP3R1; IP-3-R; IP3 receptor; IP3R 1; IP3R1; P400; type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
Homo sapiens (human) : ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)  HGNC  Alliance
Mus musculus (house mouse) : Itpr1 (inositol 1,4,5-trisphosphate receptor 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)
Canis lupus familiaris (dog) : ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr1 (inositol 1,4,5-trisphosphate receptor type 1)
Sus scrofa (pig) : ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)
Chlorocebus sabaeus (African green monkey) : ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)
Heterocephalus glaber (naked mole-rat) : Itpr1 (inositol 1,4,5-trisphosphate receptor type 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,247,313 - 140,580,748 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC3.4rn4RGSC3.4
Celera4129,839,611 - 130,162,657 (+)NCBICelera
Cytogenetic Map4q41NCBI
RH 3.4 Map4 RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itpr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2933
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.