Gene: Itpr1 (inositol 1,4,5-trisphosphate receptor, type 1) Rattus norvegicus
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Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Description: Exhibits several functions, including identical protein binding activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, and protein C-terminus binding activity; involved in several processes, including cellular response to cAMP, cellular response to hypoxia, and generation of neurons; localizes to several cellular components, including the GABA-ergic synapse, cytoplasm, and dendrite; used to study asthma; biomarker of Huntington's disease, cardiac arrest, and transient cerebral ischemia; orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor type 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 145-triphosphate receptor type 1; InsP3R; InsP3R1; IP-3-R; IP3 receptor; IP3R 1; IP3R1; P400; type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC3.4rn4RGSC3.4
Celera4129,839,611 - 130,162,657 (+)NCBICelera
Cytogenetic Map4q41NCBI
RH 3.4 Map4 RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Itpr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2933
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.