Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Itsn1 (intersectin 1) Rattus norvegicus
Symbol: Itsn1
Name: intersectin 1
CRRD ID: 2935
Description: Predicted to have kinase activator activity; molecular adaptor activity; and proline-rich region binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of growth hormone secretion; and regulation of modification of postsynaptic actin cytoskeleton. Localizes to several cellular components, including clathrin-coated pit; dendrite; and glutamatergic synapse. Orthologous to human ITSN1 (intersectin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: EH domain and SH3 domain regulator of endocytosis 1; EHSH1; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin-1; intersection (SH3 domain protein 1A); Itsn
Homo sapiens (human) : ITSN1 (intersectin 1)  HGNC  Alliance
Mus musculus (house mouse) : Itsn1 (intersectin 1 (SH3 domain protein 1A))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itsn1 (intersectin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ITSN1 (intersectin 1)
Canis lupus familiaris (dog) : ITSN1 (intersectin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itsn1 (intersectin 1)
Sus scrofa (pig) : ITSN1 (intersectin 1)
Chlorocebus sabaeus (African green monkey) : ITSN1 (intersectin 1)
Heterocephalus glaber (naked mole-rat) : Itsn1 (intersectin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01131,943,119 - 32,069,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,547,331 - 35,672,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,721,528 - 31,901,963 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11131,815,217 - 31,903,071 (+)NCBI
Celera1130,687,099 - 30,812,424 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itsn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2935
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.