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Gene: Jun (Jun proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Localizes to cytosol and nucleus. Colocalizes with nuclear chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; jun proto-oncogene; proto-oncogene c-jun; transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian)
Orthologs:
Homo sapiens (human) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)  HGNC  Alliance
Mus musculus (house mouse) : Jun (jun proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Canis lupus familiaris (dog) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)
Sus scrofa (pig) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Chlorocebus sabaeus (African green monkey) : JUN (Jun proto-oncogene, AP-1 transcription factor subunit)
Heterocephalus glaber (naked mole-rat) : Jun (Jun proto-oncogene, AP-1 transcription factor subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations