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Gene: Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) Rattus norvegicus
Symbol: Kcne1
Name: potassium voltage-gated channel subfamily E regulatory subunit 1
Description: Exhibits delayed rectifier potassium channel activity; ion channel binding activity; and potassium channel regulator activity. Predicted to contribute to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in several processes, including cellular response to acidic pH; negative regulation of protein targeting to membrane; and regulation of cation channel activity. Localizes to several cellular components, including Z disc; apical plasma membrane; and voltage-gated potassium channel complex. Colocalizes with Golgi apparatus. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to several human genes including KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
Also known as: delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Isk; m; minimal potassium channel; mink; Potassium (K+) channel protein slowly activating (Isk); potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
Cytogenetic Map11q11NCBI
RH 3.4 Map11214.7RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kcne1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2956
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.