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Gene: Kcnj8 (potassium inwardly-rectifying channel, subfamily J, member 8) Rattus norvegicus
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Symbol: Kcnj8
Name: potassium inwardly-rectifying channel, subfamily J, member 8
Description: Exhibits ATP binding activity; ATP-activated inward rectifier potassium channel activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Localizes to the inward rectifying potassium channel; mitochondrion; and sarcolemma. Used to study hypertension. Biomarker of sciatic neuropathy. Orthologous to human KCNJ8 (potassium voltage-gated channel subfamily J member 8); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); Kir6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium channel, inwardly rectifying subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; UKATP1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04176,783,287 - 176,789,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04240,996,986 - 241,003,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,144,084 - 180,149,935 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,388,422 - 180,395,042 (-)NCBI
Celera4164,042,167 - 164,048,023 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcnj8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2960
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.