Gene: Kdr (kinase insert domain receptor) Rattus norvegicus
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Symbol: Kdr
Name: kinase insert domain receptor
Description: Exhibits growth factor binding activity and vascular endothelial growth factor-activated receptor activity; involved in several processes, including aging, generation of neurons, and positive regulation of intracellular signal transduction; localizes to several cellular components, including the cytoplasm, neuron projection, and neuronal cell body; used to study brain ischemia and cystitis; biomarker of several diseases, including artery disease (multiple), colitis, endometriosis, impotence, and prostate disease (multiple); orthologous to human KDR (kinase insert domain receptor); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; vascular endothelial growth factor signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: fetal liver kinase 1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); kinase insert domain protein receptor; MGC93590; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2; Vegfr-2
Orthologs:
Homo sapiens (human) : KDR (kinase insert domain receptor)  HGNC  Alliance
Mus musculus (house mouse) : Kdr (kinase insert domain protein receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdr (kinase insert domain receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : KDR (kinase insert domain receptor)
Canis lupus familiaris (dog) : KDR (kinase insert domain receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdr (kinase insert domain receptor)
Sus scrofa (pig) : KDR (kinase insert domain receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kdr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2965
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.