Gene: Kras (KRAS proto-oncogene, GTPase) Rattus norvegicus
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Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Description: Exhibits GDP binding activity, GMP binding activity, and LRR domain binding activity; involved in several processes, including cytokine-mediated signaling pathway, female pregnancy, and response to corticosteroid; localizes to the membrane raft and mitochondrion; used to study bronchiolo-alveolar adenocarcinoma, endometrial adenocarcinoma, hepatocellular adenoma, hepatocellular carcinoma, and renal fibrosis; orthologous to human KRAS (KRAS proto-oncogene, GTPase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; endometrial cancer pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras proto-oncogene; GTPase KRas; K-Ras 2; ki-Ras; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kras2; p21; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Orthologs:
Homo sapiens (human) : KRAS (KRAS proto-oncogene, GTPase)  HGNC  Alliance
Mus musculus (house mouse) : Kras (Kirsten rat sarcoma viral oncogene homolog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kras (KRAS proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : KRAS (KRAS proto-oncogene, GTPase)
Canis lupus familiaris (dog) : KRAS (KRAS proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kras (KRAS proto-oncogene, GTPase)
Sus scrofa (pig) : KRAS (KRAS proto-oncogene, GTPase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04179,482,562 - 179,515,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04243,667,912 - 243,696,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44182,869,242 - 182,895,106 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14183,114,365 - 183,140,230 (-)NCBI
Celera4166,708,846 - 166,734,692 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kras
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2981
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.