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Gene: Lck (LCK proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
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Symbol: Lck
Name: LCK proto-oncogene, Src family tyrosine kinase
Description: Exhibits antigen binding activity and protein tyrosine kinase activity. Involved in several processes, including aging; cellular protein modification process; and positive regulation of uterine smooth muscle contraction. Localizes to several cellular components, including the glutamatergic synapse; membrane raft; and postsynaptic specialization, intracellular component. Used to study allergic conjunctivitis and human immunodeficiency virus infectious disease. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Lck1; Lck_mapped; Lcktkr; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte protein tyrosine kinase (mapped); lymphocyte-specific protein tyrosine kinase; p56-LCK; proto-oncogene tyrosine-protein kinase LCK
Orthologs:
Homo sapiens (human) : LCK (LCK proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Lck (lymphocyte protein tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05147,750,976 - 147,779,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05151,480,214 - 151,509,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,707,505 - 148,718,296 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5140,363,592 - 140,374,224 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lck
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2994
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.