Gene: Lep (leptin) Rattus norvegicus
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Symbol: Lep
Name: leptin
Description: Exhibits hormone activity and peptide hormone receptor binding activity; involved in several processes, including animal organ development, positive regulation of cell communication, and regulation of ion transport; localizes to the extracellular space; used to study several diseases, including glucose metabolism disease (multiple), hypertension, hypogonadism, neurodegenerative disease (multiple), and obesity; biomarker of Huntington's disease, familial hyperlipidemia, obesity, osteoporosis, and pre-eclampsia; orthologous to human LEP (leptin); PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OB; obese; obesity (murine homolog leptin); obesity factor
Orthologs:
Homo sapiens (human) : LEP (leptin)  HGNC  Alliance
Mus musculus (house mouse) : Lep (leptin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lep (leptin)
Pan paniscus (bonobo/pygmy chimpanzee) : LEP (leptin)
Canis lupus familiaris (dog) : LEP (leptin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lep (leptin)
Sus scrofa (pig) : LEP (leptin)
more info ...
Allele / Splice: Lepem5Mcwi   Lepm1Kyo   Lepem1Sage   Lepem1  
Genetic Models: SD-Lepem1 SD-Lepem1Sage-/- SD-Lepem1Sage+/- F344-Lepm1Kyo SS-Lepem5Mcwi
Is Marker For: Strains:   F344-Lepm1Kyo   SD-Lepem1Narl  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
Cytogenetic Map4q22NCBI
RH 3.4 Map4309.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lep
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3000
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.