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Gene: Lipe (lipase E, hormone sensitive type) Rattus norvegicus
Symbol: Lipe
Name: lipase E, hormone sensitive type
CRRD ID: 3010
Description: Exhibits carboxylic ester hydrolase activity. Involved in female pregnancy; response to drug; and triglyceride catabolic process. Localizes to cytoplasm and extracellular space. Used to study arteriosclerosis and heart disease. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 6 and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-catechin; (R)-adrenaline; (S)-nicotine.
Type: protein-coding
Also known as: Hormone - sensitive lipase testicular isoform; hormone-sensitive lipase; HSL; lipase E; lipase E, hormone sensitive; lipase hormone sensitive; lipase, hormone sensitive; monoacylglycerol lipase LIPE; REH; retinyl ester hydrolase
Homo sapiens (human) : LIPE (lipase E, hormone sensitive type)  HGNC  Alliance
Mus musculus (house mouse) : Lipe (lipase, hormone sensitive)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipe (lipase E, hormone sensitive type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPE (lipase E, hormone sensitive type)
Canis lupus familiaris (dog) : LIPE (lipase E, hormone sensitive type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lipe (lipase E, hormone sensitive type)
Sus scrofa (pig) : LIPE (lipase E, hormone sensitive type)
Chlorocebus sabaeus (African green monkey) : LIPE (lipase E, hormone sensitive type)
Heterocephalus glaber (naked mole-rat) : Lipe (lipase E, hormone sensitive type)
more info ...
Allele / Splice: Lipem1Mcwi   Lipem2Mcwi  
Genetic Models: FHH-Lipem1Mcwi BN-Lipem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lipe
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3010
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.