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Gene: Marcks (myristoylated alanine rich protein kinase C substrate) Rattus norvegicus
Symbol: Marcks
Name: myristoylated alanine rich protein kinase C substrate
Description: Exhibits phosphatidylserine binding activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Localizes to several cellular components, including anchored component of synaptic membrane; dendrite; and distal axon. Colocalizes with microtubule. Biomarker of visual epilepsy. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: KINC; LOC294446; LOC681252; Macs; myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; protein kinase C substrate 80 kDa protein; similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81); similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02042,966,140 - 42,971,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,693,252 - 44,698,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,304,058 - 41,310,104NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,329,456 - 41,332,753NCBI
Celera2041,434,118 - 41,439,860 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Marcks
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3028
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.