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Gene: Smad2 (SMAD family member 2) Rattus norvegicus
Symbol: Smad2
Name: SMAD family member 2
Description: Exhibits transcription factor binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including adrenal gland development; regulation of gene expression; and transforming growth factor beta receptor signaling pathway. Localizes to cytoplasm; nucleus; and protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 2-acetamidofluorene; 2-amino-2-deoxy-D-galactopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 2; MAD (mothers against decapentaplegic, Drosophila) homolog 2; MAD homolog 2; MAD homolog 2 (Drosophila); mad-related protein 2; Madh2; MGC156656; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; SMAD 2
Homo sapiens (human) : SMAD2 (SMAD family member 2)  HGNC  Alliance
Mus musculus (house mouse) : Smad2 (SMAD family member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad2 (SMAD family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD2 (SMAD family member 2)
Canis lupus familiaris (dog) : SMAD2 (SMAD family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad2 (SMAD family member 2)
Sus scrofa (pig) : SMAD2 (SMAD family member 2)
Chlorocebus sabaeus (African green monkey) : SMAD2 (SMAD family member 2)
Heterocephalus glaber (naked mole-rat) : Smad2 (SMAD family member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3031
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.