Gene: Smad3 (SMAD family member 3) Rattus norvegicus
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Symbol: Smad3
Name: SMAD family member 3
Description: Exhibits several functions, including DNA-binding transcription factor activity, SMAD binding activity, and beta-catenin binding activity; involved in several processes, including negative regulation of macromolecule metabolic process, positive regulation of cellular component organization, and positive regulation of cellular metabolic process; localizes to the cytoplasm, nucleus, and transcription factor complex; used to study pre-malignant neoplasm; orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (RS)-amphetamine; (S)-nicotine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
Orthologs:
Homo sapiens (human) : SMAD3 (SMAD family member 3)  HGNC  Alliance
Mus musculus (house mouse) : Smad3 (SMAD family member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad3 (SMAD family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD3 (SMAD family member 3)
Canis lupus familiaris (dog) : SMAD3 (SMAD family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad3 (SMAD family member 3)
Sus scrofa (pig) : SMAD3 (SMAD family member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Smad3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3032
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.