Gene: Smad4 (SMAD family member 4) Rattus norvegicus
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Symbol: Smad4
Name: SMAD family member 4
Description: Exhibits DNA binding activity, SMAD binding activity, and filamin binding activity; predicted to contribute to sequence-specific DNA binding activity; involved in several processes, including ERK1 and ERK2 cascade, aging, and animal organ development; localizes to the cytoplasm, nucleus, and protein-containing complex; used to study pulmonary fibrosis; biomarker of several diseases, including artery disease (multiple), hepatocellular carcinoma, lung disease (multiple), pre-malignant neoplasm, and prostatitis; orthologous to human SMAD4 (SMAD family member 4); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD (mothers against decapentaplegic, Drosophila) homolog 4; MAD homolog 4; MAD homolog 4 (Drosophila); Madh4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; SMAD 4
Orthologs:
Homo sapiens (human) : SMAD4 (SMAD family member 4)  HGNC  Alliance
Mus musculus (house mouse) : Smad4 (SMAD family member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad4 (SMAD family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD4 (SMAD family member 4)
Canis lupus familiaris (dog) : SMAD4 (SMAD family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad4 (SMAD family member 4)
Sus scrofa (pig) : SMAD4 (SMAD family member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Smad4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3033
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.