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Gene: Mat1a (methionine adenosyltransferase 1A) Rattus norvegicus
Symbol: Mat1a
Name: methionine adenosyltransferase 1A
CRRD ID: 3050
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Localizes to cytosol and nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A); PARTICIPATES IN methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AdoMet; adoMet synthase 1; adoMet synthetase 1; MAT 1; MAT-I/III; methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; methionine adenosyltransferase I/III; MGC108563; S - adenosylmethionine synthetase; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthetase isoform type-1; SADE; SAS
Homo sapiens (human) : MAT1A (methionine adenosyltransferase 1A)  HGNC  Alliance
Mus musculus (house mouse) : Mat1a (methionine adenosyltransferase I, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mat1a (methionine adenosyltransferase 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : MAT1A (methionine adenosyltransferase 1A)
Canis lupus familiaris (dog) : MAT1A (methionine adenosyltransferase 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mat1a (methionine adenosyltransferase 1A)
Sus scrofa (pig) : MAT1A (methionine adenosyltransferase 1A)
Chlorocebus sabaeus (African green monkey) : MAT1A (methionine adenosyltransferase 1A)
Heterocephalus glaber (naked mole-rat) : Mat1a (methionine adenosyltransferase 1A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01618,690,649 - 18,709,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,690,246 - 18,709,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,560,492 - 18,578,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,548,582 - 17,563,989 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,548,582 - 17,562,884 (+)NCBI
Celera1617,208,280 - 17,226,582 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mat1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3050
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.