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Gene: Mbp (myelin basic protein) Rattus norvegicus
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Symbol: Mbp
Name: myelin basic protein
Description: A structural constituent of myelin sheath. Involved in several processes, including nervous system development; response to progesterone; and response to tumor necrosis factor. Localizes to cell surface and compact myelin. Used to study demyelinating disease. Biomarker of Huntington's disease; brain disease (multiple); diabetic neuropathy; and schizophrenia. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Golli-Mbp; MBP S; Mbps; myelin basic protein Golli-mbp; myelin basic protein S
Orthologs:
Homo sapiens (human) : MBP (myelin basic protein)  HGNC  Alliance
Mus musculus (house mouse) : Mbp (myelin basic protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbp (myelin basic protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MBP (myelin basic protein)
Canis lupus familiaris (dog) : MBP (myelin basic protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mbp (myelin basic protein)
Sus scrofa (pig) : MBP (myelin basic protein)
Chlorocebus sabaeus (African green monkey) : MBP (myelin basic protein)
Heterocephalus glaber (naked mole-rat) : Mbp (myelin basic protein)
more info ...
Allele / Splice: Mbpmd  
Genetic Models: LE-Mbpmd
Is Marker For: Strains:   LE-Mbpmd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01879,326,738 - 79,437,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1879,326,738 - 79,437,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01878,385,304 - 78,504,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41878,943,608 - 79,057,329 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11879,098,861 - 79,130,602 (+)NCBI
Celera1874,493,165 - 74,602,969 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mbp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3054
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.