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Gene: Mc4r (melanocortin 4 receptor) Rattus norvegicus
Symbol: Mc4r
Name: melanocortin 4 receptor
CRRD ID: 3057
Description: Exhibits melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Localizes to nucleus and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MC4-R; melanocortin receptor 4
Homo sapiens (human) : MC4R (melanocortin 4 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Mc4r (melanocortin 4 receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mc4r (melanocortin 4 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MC4R (melanocortin 4 receptor)
Canis lupus familiaris (dog) : MC4R (melanocortin 4 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mc4r (melanocortin 4 receptor)
Sus scrofa (pig) : MC4R (melanocortin 4 receptor)
Chlorocebus sabaeus (African green monkey) : MC4R (melanocortin 4 receptor)
Heterocephalus glaber (naked mole-rat) : Mc4r (melanocortin 4 receptor)
more info ...
Allele / Splice: Mc4rm1Hubr  
Genetic Models: WI-Mc4rm1Hubr
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01862,612,838 - 62,614,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,799,166 - 61,801,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,390,922 - 63,392,809 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11863,464,122 - 63,465,631 (-)NCBI
Celera1858,529,070 - 58,530,957 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
RH 3.4 Map18610.4RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mc4r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3057
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.