Gene: Mecp2 (methyl CpG binding protein 2) Rattus norvegicus
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Symbol: Mecp2
Name: methyl CpG binding protein 2
Description: Exhibits several functions, including DNA binding activity, histone deacetylase binding activity, and promoter-specific chromatin binding activity; involved in several processes, including animal organ development, nervous system development, and regulation of nucleobase-containing compound metabolic process; localizes to several cellular components, including the cytosol, glutamatergic synapse, and nuclear chromatin; used to study Rett syndrome; biomarker of attention deficit hyperactivity disorder, hepatocellular carcinoma, transient cerebral ischemia, and visual epilepsy; orthologous to human MECP2 (methyl-CpG binding protein 2); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: meCP-2 protein; methyl-CpG-binding protein 2
Orthologs:
Homo sapiens (human) : MECP2 (methyl-CpG binding protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Mecp2 (methyl CpG binding protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecp2 (methyl-CpG binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MECP2 (methyl-CpG binding protein 2)
Canis lupus familiaris (dog) : MECP2 (methyl-CpG binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecp2 (methyl-CpG binding protein 2)
Sus scrofa (pig) : MECP2 (methyl-CpG binding protein 2)
more info ...
Allele / Splice: Mecp2em1Sage  
Genetic Models: SD-Mecp2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mecp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3075
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.