Gene: Met (MET proto-oncogene, receptor tyrosine kinase) Rattus norvegicus
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Symbol: Met
Name: MET proto-oncogene, receptor tyrosine kinase
Description: Exhibits several functions, including beta-catenin binding activity, hepatocyte growth factor-activated receptor activity, and phosphatidylinositol 3-kinase binding activity; involved in several processes, including animal organ development, nervous system development, and positive regulation of cellular metabolic process; localizes to several cellular components, including the cytoplasm, dendrite, and excitatory synapse; biomarker of several diseases, including acute kidney failure, carcinoma (multiple), endocrine gland cancer (multiple), liver benign neoplasm, and malignant glioma; orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN scatter factor/hepatocyte growth factor signaling pathway; altered scatter factor/hepatocyte growth factor signaling pathway; non-small cell lung carcinoma pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-Met; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Hgfr; met proto-oncogene; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; SF receptor; tyrosine-protein kinase Met
Orthologs:
Homo sapiens (human) : MET (MET proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Met (met proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Met (MET proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MET (MET proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : MET (MET proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Met (MET proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : MET (MET proto-oncogene, receptor tyrosine kinase)
more info ...
Allele / Splice: Metem1Sage  
Genetic Models: SD-Metem1Sage
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0444,747,467 - 44,854,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,354,290 - 45,461,638 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,134,183 - 43,211,355 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,280,529 - 43,358,391 (+)NCBI
Celera441,091,921 - 41,169,063 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Met
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3082
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.