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Gene: Mgmt (O-6-methylguanine-DNA methyltransferase) Rattus norvegicus
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Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Description: Exhibits calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Localizes to the nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); malignant glioma (multiple); retinoblastoma; and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase); INTERACTS WITH (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; O(6)-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase
Orthologs:
Homo sapiens (human) : MGMT (O-6-methylguanine-DNA methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Mgmt (O-6-methylguanine-DNA methyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mgmt (O-6-methylguanine-DNA methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : MGMT (O-6-methylguanine-DNA methyltransferase)
Canis lupus familiaris (dog) : MGMT (O-6-methylguanine-DNA methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mgmt (O-6-methylguanine-DNA methyltransferase)
Sus scrofa (pig) : MGMT (O-6-methylguanine-DNA methyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01209,237,255 - 209,464,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01216,161,345 - 216,388,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41196,629,366 - 196,866,937 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11196,779,357 - 197,016,929 (+)NCBI
Celera1189,418,812 - 189,644,779 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mgmt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3087
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.