Gene: Nefh (neurofilament heavy) Rattus norvegicus
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Symbol: Nefh
Name: neurofilament heavy
Description: Exhibits protein binding activity, bridging, protein heterodimerization activity, and toxic substance binding activity; involved in several processes, including animal organ development, cellular response to estradiol stimulus, and cellular response to oxidative stress; localizes to several cellular components, including the axon, cytoplasm, and intracellular organelle; used to study congenital hypothyroidism; biomarker of hypothyroidism, phenylketonuria, sciatic neuropathy, and transient cerebral ischemia; orthologous to human NEFH (neurofilament heavy); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-adrenaline; 1,2-dichlorobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 200 kDa neurofilament protein; neurofilament heavy polypeptide; neurofilament triplet H protein; neurofilament, heavy polypeptide; NF-H; Nfh
Orthologs:
Homo sapiens (human) : NEFH (neurofilament heavy)  HGNC  Alliance
Mus musculus (house mouse) : Nefh (neurofilament, heavy polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefh (neurofilament heavy)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFH (neurofilament heavy)
Canis lupus familiaris (dog) : NEFH (neurofilament heavy)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefh (neurofilament heavy)
Sus scrofa (pig) : NEFH (neurofilament heavy)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01485,181,572 - 85,191,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01485,859,193 - 85,869,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,594,789 - 85,604,774 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11485,614,415 - 85,623,919 (-)NCBI
Celera1478,720,827 - 78,730,812 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nefh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3159
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.