Gene: Nppa (natriuretic peptide A) Rattus norvegicus
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Symbol: Nppa
Name: natriuretic peptide A
Description: Exhibits hormone activity; involved in several processes, including cGMP-mediated signaling, cell growth involved in cardiac muscle cell development, and regulation of ion transport; localizes to the mast cell granule, nucleus, and perinuclear region of cytoplasm; used to study congestive heart failure, pulmonary hypertension, and ureteral obstruction; biomarker of acute kidney failure, artery disease (multiple), hypertrophic cardiomyopathy, and nephrosis; orthologous to human NPPA (natriuretic peptide A); PARTICIPATES IN atrial natriuretic peptide signaling pathway; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANF; ANP; atrial natriuretic factor; atrial natriuretic peptide; Natriuretic peptide precursor A (pronatriodilatin also Anf Pnd); Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); Natriuretic peptide precursor A, (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; natriuretic peptides A; Pnd; prepronatriodilatin; RATANF
Orthologs:
Homo sapiens (human) : NPPA (natriuretic peptide A)  HGNC  Alliance
Mus musculus (house mouse) : Nppa (natriuretic peptide type A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppa (natriuretic peptide A)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPA (natriuretic peptide A)
Canis lupus familiaris (dog) : NPPA (natriuretic peptide A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppa (natriuretic peptide A)
Sus scrofa (pig) : NPPA (natriuretic peptide A)
more info ...
Allele / Splice: Nppaem4Mcwi  
Genetic Models: SS-Nppaem4Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp49   Strs2   Bp100   Strs6  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map51106.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nppa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3193
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.