Gene: Npr1 (natriuretic peptide receptor 1) Rattus norvegicus
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Symbol: Npr1
Name: natriuretic peptide receptor 1
Description: Exhibits guanylate cyclase activity and protein kinase binding activity; involved in several processes, including cGMP-mediated signaling, cell surface receptor signaling pathway, and dopamine metabolic process; localizes to the plasma membrane; used to study hypertension; orthologous to human NPR1 (natriuretic peptide receptor 1); PARTICIPATES IN atrial natriuretic peptide signaling pathway; brain natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH (RS)-amphetamine; 2,6-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ANP-A; ANPR-A; Anpra; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; GC-A; Gca; guanylate cyclase A; Natriuretic peptide receptor A/Guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; Npra
Orthologs:
Homo sapiens (human) : NPR1 (natriuretic peptide receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Npr1 (natriuretic peptide receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr1 (natriuretic peptide receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR1 (natriuretic peptide receptor 1)
Canis lupus familiaris (dog) : NPR1 (natriuretic peptide receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr1 (natriuretic peptide receptor 1)
Sus scrofa (pig) : NPR1 (natriuretic peptide receptor 1)
more info ...
Is Marker For: Strains:   SS.MNS-(Mme-Gca)/Ayd  
QTLs:   Niddm8   Bp19   Cm67   Bp363   Kidm56   Bw176  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02189,840,403 - 189,857,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02209,271,276 - 209,287,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,724,916 - 182,740,242 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12182,675,021 - 182,690,348 (-)NCBI
Celera2169,869,831 - 169,885,101 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Npr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3195
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.