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Gene: Npy (neuropeptide Y) Rattus norvegicus
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Symbol: Npy
Name: neuropeptide Y
Description: Exhibits neuropeptide Y receptor binding activity. Involved in several processes, including adult feeding behavior; positive regulation of appetite; and positive regulation of nitrogen compound metabolic process. Localizes to several cellular components, including neuronal dense core vesicle; perikaryon; and perinuclear region of cytoplasm. Used to study alcohol use disorder; childhood absence epilepsy; hypertension; and mental depression. Biomarker of several diseases, including brain disease (multiple); median neuropathy; mental depression; neurodegenerative disease (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol use disorder; artery disease (multiple); epilepsy (multiple); and type 2 diabetes mellitus. Orthologous to human NPY (neuropeptide Y); PARTICIPATES IN neuropeptide Y metabolic pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NPY02; pro-neuropeptide Y; RATNPY; RATNPY02
Orthologs:
Homo sapiens (human) : NPY (neuropeptide Y)  HGNC  Alliance
Mus musculus (house mouse) : Npy (neuropeptide Y)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npy (neuropeptide Y)
Pan paniscus (bonobo/pygmy chimpanzee) : NPY (neuropeptide Y)
Canis lupus familiaris (dog) : NPY (neuropeptide Y)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npy (neuropeptide Y)
Sus scrofa (pig) : NPY (neuropeptide Y)
Chlorocebus sabaeus (African green monkey) : NPY (neuropeptide Y)
Heterocephalus glaber (naked mole-rat) : Npy (neuropeptide Y)
more info ...
Allele / Splice: Npyem6Sage  
Genetic Models: NP/Iusm-Npyem6Sage NP/Iusm-Npyem6Sage-/- NP/Iusm-Npyem6Sage+/-
Is Marker For: Strains:   SHR.BN-(Il6-Npy)   P   NP   BB.SHR-(D4Mit6-Spr)/K   NP.P-(D4Rat119-D4Rat55)/Iusm  
QTLs:   Bp21   Bp135  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0479,557,856 - 79,565,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,233,753 - 144,240,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,038,013 - 78,045,187 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1478,314,142 - 78,321,317 (+)NCBI
Celera473,795,148 - 73,802,371 (+)NCBICelera
Cytogenetic Map4q24NCBI
RH 3.4 Map4507.8RGD
RH 3.4 Map4508.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Npy
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3197
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.