Gene: P4hb (prolyl 4-hydroxylase subunit beta) Rattus norvegicus
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Symbol: P4hb
Name: prolyl 4-hydroxylase subunit beta
Description: Exhibits enzyme binding activity, protein disulfide isomerase activity, and protein heterodimerization activity; predicted to contribute to procollagen-proline 4-dioxygenase activity; predicted to be involved in several processes, including cellular response to hypoxia, cellular response to interleukin-7, and peptidyl-proline hydroxylation to 4-hydroxy-L-proline; predicted to localize to the cytoplasm, external side of plasma membrane, and intracellular organelle; orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular thyroid hormone-binding protein; PDI; PDIR; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide-isomerase
Orthologs:
Homo sapiens (human) : P4HB (prolyl 4-hydroxylase subunit beta)  HGNC  Alliance
Mus musculus (house mouse) : P4hb (prolyl 4-hydroxylase, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P4hb (prolyl 4-hydroxylase subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : P4HB (prolyl 4-hydroxylase subunit beta)
Canis lupus familiaris (dog) : P4HB (prolyl 4-hydroxylase subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P4hb (prolyl 4-hydroxylase subunit beta)
Sus scrofa (pig) : P4HB (prolyl 4-hydroxylase subunit beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on P4hb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3244
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.