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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
Description: Exhibits protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to lipid; and cellular response to organonitrogen compound. Localizes to chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal failure; and hematopoietic system disease (multiple). Biomarker of several diseases, including glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; muscular atrophy; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-colchicine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthologs:
Homo sapiens (human) : SERPINE1 (serpin family E member 1)  HGNC  Alliance
Mus musculus (house mouse) : Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine1 (serpin family E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE1 (serpin family E member 1)
Canis lupus familiaris (dog) : SERPINE1 (serpin family E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine1 (serpin family E member 1)
Sus scrofa (pig) : SERPINE1 (serpin family E member 1)
Chlorocebus sabaeus (African green monkey) : SERPINE1 (serpin family E member 1)
Heterocephalus glaber (naked mole-rat) : Serpine1 (serpin family E member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
Cytogenetic Map12q12NCBI
RH 3.4 Map12277.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Serpine1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3249
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.