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Gene: Pak1 (p21 (RAC1) activated kinase 1) Rattus norvegicus
Symbol: Pak1
Name: p21 (RAC1) activated kinase 1
Description: Exhibits protein kinase binding activity and protein serine/threonine kinase activity. Predicted to contribute to Rac GTPase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Localizes to several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: alpha-PAK; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; PAK-1; protein kinase MUK2; serine/threonine-protein kinase PAK 1
Homo sapiens (human) : PAK1 (p21 (RAC1) activated kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pak1 (p21 (RAC1) activated kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak1 (p21 (RAC1) activated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK1 (p21 (RAC1) activated kinase 1)
Canis lupus familiaris (dog) : PAK1 (p21 (RAC1) activated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak1 (p21 (RAC1) activated kinase 1)
Sus scrofa (pig) : PAK1 (p21 (RAC1) activated kinase 1)
Chlorocebus sabaeus (African green monkey) : PAK1 (p21 (RAC1) activated kinase 1)
Heterocephalus glaber (naked mole-rat) : Pak1 (p21 (RAC1) activated kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Celera1150,203,043 - 150,317,598 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pak1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3250
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.