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Gene: Pcsk1 (proprotein convertase subtilisin/kexin type 1) Rattus norvegicus
Symbol: Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Description: Exhibits chaperone binding activity; endopeptidase activity; and insulin binding activity. Involved in several processes, including nervous system development; protein processing; and response to morphine. Localizes to several cellular components, including perikaryon; rough endoplasmic reticulum; and trans-Golgi network. Colocalizes with secretory granule. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; melanocortin system pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BDP; NEC 1; neuroendocrine convertase 1; PC1; PC3; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I
Homo sapiens (human) : PCSK1 (proprotein convertase subtilisin/kexin type 1)  HGNC  Alliance
Mus musculus (house mouse) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Canis lupus familiaris (dog) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)
Sus scrofa (pig) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Chlorocebus sabaeus (African green monkey) : PCSK1 (proprotein convertase subtilisin/kexin type 1)
Heterocephalus glaber (naked mole-rat) : Pcsk1 (proprotein convertase subtilisin/kexin type 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0291,450,162 - 91,497,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl291,450,162 - 91,497,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,274,882 - 2,309,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,923,309 - 1,970,238 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.121,937,434 - 1,981,975 (+)NCBI
Celera2885,989 - 932,918 (+)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pcsk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3272
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.