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Gene: Furin (furin (paired basic amino acid cleaving enzyme)) Rattus norvegicus
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Symbol: Furin
Name: furin (paired basic amino acid cleaving enzyme)
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; and protein processing. Localizes to Golgi cisterna; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; INTERACTS WITH (+)-schisandrin B; 7,12-dimethyltetraphene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dibasic-processing enzyme; LOC360309; Pace; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; prohormone convertase 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme furin membrane associated receptor protein); Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3
Orthologs:
Homo sapiens (human) : FURIN (furin, paired basic amino acid cleaving enzyme)  HGNC  Alliance
Mus musculus (house mouse) : Furin (furin (paired basic amino acid cleaving enzyme))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Furin (furin, paired basic amino acid cleaving enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : FURIN (furin, paired basic amino acid cleaving enzyme)
Canis lupus familiaris (dog) : FURIN (furin, paired basic amino acid cleaving enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Furin (furin, paired basic amino acid cleaving enzyme)
Sus scrofa (pig) : FURIN (furin, paired basic amino acid cleaving enzyme)
Chlorocebus sabaeus (African green monkey) : FURIN (furin, paired basic amino acid cleaving enzyme)
Heterocephalus glaber (naked mole-rat) : Furin (furin, paired basic amino acid cleaving enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
Cytogenetic Map1q31NCBI
RH 3.4 Map11074.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Furin
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3274
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.