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Gene: Pde4a (phosphodiesterase 4A) Rattus norvegicus
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Symbol: Pde4a
Name: phosphodiesterase 4A
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity and cAMP binding activity. Involved in modulation of chemical synaptic transmission and response to drug. Localizes to the Schaffer collateral - CA1 synapse; cytoplasm; and nucleus. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; 4-nitrophenyl beta-D-xyloside; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; DPDE2; PHOSA; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
Orthologs:
Homo sapiens (human) : PDE4A (phosphodiesterase 4A)  HGNC  Alliance
Mus musculus (house mouse) : Pde4a (phosphodiesterase 4A, cAMP specific)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4a (phosphodiesterase 4A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4A (phosphodiesterase 4A)
Canis lupus familiaris (dog) : PDE4A (phosphodiesterase 4A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4a (phosphodiesterase 4A)
Sus scrofa (pig) : PDE4A (phosphodiesterase 4A)
more info ...
Allele / Splice: Pde4a_v1   Pde4a_v3   Pde4a_v2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0822,189,533 - 22,234,036 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,245,707 - 22,289,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,192,677 - 20,241,557 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,192,676 - 20,241,557 (+)NCBI
Celera821,100,973 - 21,145,549 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pde4a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3279
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.