Gene: Pde4b (phosphodiesterase 4B) Rattus norvegicus
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Symbol: Pde4b
Name: phosphodiesterase 4B
Description: Exhibits 3',5'-cyclic-AMP phosphodiesterase activity; involved in response to heat; localizes to the cytosol, nucleus, and perinuclear region of cytoplasm; orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; MGC93193; PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4); phosphodiesterase 4B, cAMP specific; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, variant 1; phosphodiesterase 4B, variant 2; phosphodiesterase 4B, variant 3; phosphodiesterase 4B, variant 4; phosphodiesterase type 4B5
Orthologs:
Homo sapiens (human) : PDE4B (phosphodiesterase 4B)  HGNC  Alliance
Mus musculus (house mouse) : Pde4b (phosphodiesterase 4B, cAMP specific)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4b (phosphodiesterase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4B (phosphodiesterase 4B)
Canis lupus familiaris (dog) : PDE4B (phosphodiesterase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4b (phosphodiesterase 4B)
Sus scrofa (pig) : PDE4B (phosphodiesterase 4B)
more info ...
Allele / Splice: Pde4bem1Sage  
Genetic Models: SD-Pde4bem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Celera5115,579,422 - 115,946,626 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pde4b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3280
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.