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Gene: Abcb1b (ATP-binding cassette, subfamily B (MDR/TAP), member 1B) Rattus norvegicus
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Symbol: Abcb1b
Name: ATP-binding cassette, subfamily B (MDR/TAP), member 1B
Description: Predicted to have ATPase-coupled intramembrane lipid transporter activity and ATPase-coupled transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; animal organ development; and cellular response to external biotic stimulus. Localizes to Golgi membrane and external side of apical plasma membrane. Used to study brain disease (multiple); colorectal adenocarcinoma; end stage renal failure; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; allergic rhinitis; carcinoma (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Abcb1; ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; Mdr1; mdr1b; multidrug resistance protein 1; P-glycoprotein 1; P-glycoprotein/multidrug resistance 1; Pgy1; phospholipid transporter ABCB1
Orthologs:
Allele / Splice: Abcb1bem2Mcwi  
Genetic Models: SS-Abcb1bem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0422,225,123 - 22,307,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,161,597 - 22,244,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,829,489 - 21,912,239 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1421,829,488 - 21,912,239 (+)NCBI
Celera420,736,092 - 20,817,649 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Abcb1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3318
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.