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Gene: Phb (prohibitin) Rattus norvegicus
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Symbol: Phb
Name: prohibitin
Description: Predicted to have several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including animal organ regeneration; female gonad development; and response to ethanol. Localizes to several cellular components, including the GABA-ergic synapse; extrinsic component of presynaptic active zone membrane; and mitochondrial membrane. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB (prohibitin); INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Orthologs:
Homo sapiens (human) : PHB (prohibitin)  HGNC  Alliance
Mus musculus (house mouse) : Phb (prohibitin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phb (prohibitin)
Pan paniscus (bonobo/pygmy chimpanzee) : PHB (prohibitin)
Canis lupus familiaris (dog) : PHB (prohibitin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phb (prohibitin)
Sus scrofa (pig) : PHB (prohibitin)
more info ...
Related Pseudogenes: Phb-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)Ensembl
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Phb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3322
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.