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Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) Rattus norvegicus
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Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
CRRD ID: 3329
Description: Exhibits several functions, including 1-phosphatidylinositol-3-kinase regulator activity; enzyme binding activity; and signaling receptor binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of phosphorylation; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to several cellular components, including neuron projection; nucleus; and phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial cancer (multiple); immunodeficiency 36; and lung small cell carcinoma. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1); PARTICIPATES IN insulin signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide 3-kinase p85; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase regulatory subunit polypeptide 1 (p85 alpha); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3KA; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
Orthologs:
Homo sapiens (human) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Canis lupus familiaris (dog) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Sus scrofa (pig) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Chlorocebus sabaeus (African green monkey) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Heterocephalus glaber (naked mole-rat) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
Cytogenetic Map2q12NCBI
RH 3.4 Map2111.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pik3r1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3329
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.