Gene: Pitx2 (paired-like homeodomain 2) Rattus norvegicus
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Symbol: Pitx2
Name: paired-like homeodomain 2
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity; involved in several processes, including animal organ development, nervous system development, and positive regulation of transcription by RNA polymerase II; localizes to the nucleus; biomarker of autosomal dominant polycystic kidney disease and hypothyroidism; orthologous to human PITX2 (paired like homeodomain 2); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; acrylamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein PITX2; homeodomain transcription factor 2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; Pitx-2; Pitx2c; Ptx2; rPtx2
Orthologs:
Homo sapiens (human) : PITX2 (paired like homeodomain 2)  HGNC  Alliance
Mus musculus (house mouse) : Pitx2 (paired-like homeodomain transcription factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pitx2 (paired like homeodomain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PITX2 (paired like homeodomain 2)
Canis lupus familiaris (dog) : PITX2 (paired like homeodomain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pitx2 (paired like homeodomain 2)
Sus scrofa (pig) : PITX2 (paired like homeodomain 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pitx2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3331
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.