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Gene: Pkm (pyruvate kinase M1/2) Rattus norvegicus
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Symbol: Pkm
Name: pyruvate kinase M1/2
Description: Exhibits several functions, including ADP binding activity; pyruvate kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; protein homotetramerization; and pyruvate metabolic process. Localizes to the pyruvate kinase complex. Orthologous to human PKM (pyruvate kinase M1/2); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; hypoxia inducible factor pathway; INTERACTS WITH (R)-adrenaline; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: M2 pyruvate kinase; PK; Pk3; PKM12; Pkm2; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase PKM; pyruvate kinase, muscle
Orthologs:
Homo sapiens (human) : PKM (pyruvate kinase M1/2)  HGNC  Alliance
Mus musculus (house mouse) : Pkm (pyruvate kinase, muscle)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pkm (pyruvate kinase M1/2)
Pan paniscus (bonobo/pygmy chimpanzee) : PKM (pyruvate kinase M1/2)
Canis lupus familiaris (dog) : PKM (pyruvate kinase M1/2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pkm (pyruvate kinase M1/2)
Sus scrofa (pig) : PKM (pyruvate kinase, muscle)
more info ...
Allele / Splice: Pkm_v2   Pkm_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0864,480,963 - 64,502,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0864,243,957 - 64,265,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4863,486,492 - 63,508,016 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1863,505,545 - 63,527,070 (+)NCBI
Celera859,500,837 - 59,522,361 (+)NCBICelera
Cytogenetic Map8q24NCBI
RH 3.4 Map8703.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pkm
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3337
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.