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Gene: Plau (plasminogen activator, urokinase) Rattus norvegicus
Symbol: Plau
Name: plasminogen activator, urokinase
Description: Exhibits peptidase activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to staurosporine; and positive regulation of ovulation. Localizes to extracellular space and membrane. Used to study several diseases, including alcoholic liver cirrhosis; lung disease (multiple); sciatic neuropathy; status epilepticus; and transient cerebral ischemia. Biomarker of brain disease (multiple); end stage renal failure; myocardial infarction; sciatic neuropathy; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase); PARTICIPATES IN fibrinolysis pathway; fibroblast growth factor signaling pathway; coagulation cascade pathway; INTERACTS WITH (+)-catechin; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: MGC124931; U-plasminogen activator; uPA; UPAM; Urinary plasminogen activator urokinase; Urinary plasminogen activator, urokinase; urokinase plasminogen activator; urokinase-type plasminogen activator
Homo sapiens (human) : PLAU (plasminogen activator, urokinase)  HGNC  Alliance
Mus musculus (house mouse) : Plau (plasminogen activator, urokinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plau (plasminogen activator, urokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAU (plasminogen activator, urokinase)
Canis lupus familiaris (dog) : PLAU (plasminogen activator, urokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plau (plasminogen activator, urokinase)
Sus scrofa (pig) : PLAU (plasminogen activator, urokinase)
Chlorocebus sabaeus (African green monkey) : PLAU (plasminogen activator, urokinase)
Heterocephalus glaber (naked mole-rat) : Plau (plasminogen activator, urokinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0153,644,296 - 3,650,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,644,769 - 3,650,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,621,057 - 3,627,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,680,072 - 3,686,232 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,680,073 - 3,686,275 (-)NCBI
Celera151,129,191 - 1,135,694 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plau
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3343
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.