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Gene: Pou1f1 (POU class 1 homeobox 1) Rattus norvegicus
Symbol: Pou1f1
Name: POU class 1 homeobox 1
CRRD ID: 3367
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Localizes to nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride; bisphenol A.
Type: protein-coding
Also known as: GHF-1; GHF1; GHF1A; growth hormone factor 1; homeodomain protein for Growth Hormone (GH); pit-1; Pit1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1
Homo sapiens (human) : POU1F1 (POU class 1 homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Pou1f1 (POU domain, class 1, transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pou1f1 (POU class 1 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : POU1F1 (POU class 1 homeobox 1)
Canis lupus familiaris (dog) : POU1F1 (POU class 1 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pou1f1 (POU class 1 homeobox 1)
Sus scrofa (pig) : POU1F1 (POU class 1 homeobox 1)
Chlorocebus sabaeus (African green monkey) : POU1F1 (POU class 1 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Pou1f1 (POU class 1 homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0112,645,659 - 2,662,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,645,865 - 2,662,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0112,630,048 - 2,647,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,959,383 - 2,980,545 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1112,959,382 - 2,980,543 (+)NCBI
Celera113,294,195 - 3,311,824 (+)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pou1f1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3367
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.