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Gene: Ppp2ca (protein phosphatase 2 catalytic subunit alpha) Rattus norvegicus
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Description: Exhibits several functions, including beta-2 adrenergic receptor binding activity; enzyme binding activity; and ion channel binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of protein metabolic process. Localizes to several cellular components, including postsynaptic density; protein phosphatase type 2A complex; and terminal bouton. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; dopamine signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC103694903; PP2A-alpha; Pp2a1; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Celera1035,713,154 - 35,732,937 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ppp2ca
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3380
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.