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Gene: Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Rattus norvegicus
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Symbol: Ppp3ca
Name: protein phosphatase 3 catalytic subunit alpha
CRRD ID: 3382
Description: Exhibits calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and response to amphetamine. Localizes to calcineurin complex; cytosol; and synapse. Colocalizes with slit diaphragm. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcineurin subunit A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; Calna1; CAM-PRP catalytic subunit; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Orthologs:
Homo sapiens (human) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Canis lupus familiaris (dog) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Sus scrofa (pig) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Chlorocebus sabaeus (African green monkey) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Heterocephalus glaber (naked mole-rat) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02241,909,332 - 242,186,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2241,909,832 - 242,184,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02260,463,144 - 260,737,186 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42234,130,176 - 234,409,232 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12234,116,915 - 234,395,972 (+)NCBI
Celera2217,359,756 - 217,630,340 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ppp3ca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3382
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.