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Gene: Ppp3cb (protein phosphatase 3 catalytic subunit beta) Rattus norvegicus
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Symbol: Ppp3cb
Name: protein phosphatase 3 catalytic subunit beta
Description: Exhibits calcium-dependent protein serine/threonine phosphatase activity and calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Localizes to plasma membrane; protein-containing complex; and synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcineurin subunit A beta; calmodulin-dependent calcineurin A subunit beta isoform; Calna2; CAM-PRP catalytic subunit; CaN Abeta; CNA beta; protein phosphatase 3, catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase-2Bb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Orthologs:
Homo sapiens (human) : PPP3CB (protein phosphatase 3 catalytic subunit beta)  HGNC  Alliance
Mus musculus (house mouse) : Ppp3cb (protein phosphatase 3, catalytic subunit, beta isoform)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Canis lupus familiaris (dog) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Sus scrofa (pig) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Chlorocebus sabaeus (African green monkey) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Heterocephalus glaber (naked mole-rat) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0154,209,702 - 4,236,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,310,717 - 8,338,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,986,290 - 4,030,352 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X153,471,064 - 153,474,197 (+)NCBI
Celera15790,760 - 817,953 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ppp3cb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3383
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.