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Gene: Prkcz (protein kinase C, zeta) Rattus norvegicus
Symbol: Prkcz
Name: protein kinase C, zeta
CRRD ID: 3399
Description: Exhibits several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of phospholipase D activity; activation of protein kinase B activity; and positive regulation of cell communication. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and stress fiber. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta); PARTICIPATES IN angiotensin II signaling pathway; epidermal growth factor/neuregulin signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 2-methoxyethanol.
Type: protein-coding
Also known as: 14 - 3 - 3 - zeta isoform; 14-3-3-zetaisoform; nPKC-zeta; Pkcz; protein kinase C zeta type; r14-3-3
Homo sapiens (human) : PRKCZ (protein kinase C zeta)  HGNC  Alliance
Mus musculus (house mouse) : Prkcz (protein kinase C, zeta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcz (protein kinase C zeta)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCZ (protein kinase C zeta)
Canis lupus familiaris (dog) : PRKCZ (protein kinase C zeta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcz (protein kinase C zeta)
Sus scrofa (pig) : PRKCZ (protein kinase C zeta)
Chlorocebus sabaeus (African green monkey) : PRKCZ (protein kinase C zeta)
Heterocephalus glaber (naked mole-rat) : Prkcz (protein kinase C zeta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05172,658,071 - 172,769,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,658,748 - 172,769,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,116,787 - 176,228,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,061,825 - 172,172,793 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15172,072,319 - 172,179,534 (-)NCBI
Celera5164,023,257 - 164,132,959 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkcz
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3399
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.