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Gene: Prlr (prolactin receptor) Rattus norvegicus
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Symbol: Prlr
Name: prolactin receptor
Description: Exhibits prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; gland development; and positive regulation of cold-induced thermogenesis. Predicted to localize to the external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: lactogen receptor; MGC105486; PRL-R; RATPRLR
Orthologs:
Homo sapiens (human) : PRLR (prolactin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Prlr (prolactin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prlr (prolactin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PRLR (prolactin receptor)
Canis lupus familiaris (dog) : PRLR (prolactin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prlr (prolactin receptor)
Sus scrofa (pig) : PRLR (prolactin receptor)
more info ...
Is Marker For: Strains:   SD   SS.LEW-(Prlr-D2Rat143)/Ayd  
QTLs:   Bp99   Smcn1   Bp270  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0260,131,410 - 60,325,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0284,360,850 - 84,554,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Celera259,347,111 - 59,534,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prlr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3407
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.