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Gene: Prnp (prion protein) Rattus norvegicus
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Symbol: Prnp
Name: prion protein
Description: Exhibits several functions, including ATP-dependent protein binding activity; chaperone binding activity; and ion channel binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Localizes to the cytoplasm; plasma membrane; and postsynaptic density. Predicted to colocalize with the dendrite and membrane raft. Used to study hyperglycemia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: major prion protein; Prion protein structural; prion protein, PrP; Prion protein, structural; Prn; PrP
Orthologs:
Homo sapiens (human) : PRNP (prion protein)  HGNC  Alliance
Mus musculus (house mouse) : Prnp (prion protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prnp (prion protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PRNP (prion protein)
Canis lupus familiaris (dog) : PRNP (prion protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prnp (prion protein)
Sus scrofa (pig) : PRNP (prion protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Celera3117,986,209 - 118,001,394 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prnp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3410
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.