Gene: Ptgis (prostaglandin I2 synthase) Rattus norvegicus
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Symbol: Ptgis
Name: prostaglandin I2 synthase
Description: Exhibits prostaglandin-I synthase activity; involved in prostaglandin biosynthetic process and response to hypoxia; localizes to the extracellular space; used to study brain ischemia and pulmonary hypertension; orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (R)-carnitine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PGIS; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase
Orthologs:
Homo sapiens (human) : PTGIS (prostaglandin I2 synthase)  HGNC  Alliance
Mus musculus (house mouse) : Ptgis (prostaglandin I2 (prostacyclin) synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgis (prostaglandin I2 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGIS (prostaglandin I2 synthase)
Canis lupus familiaris (dog) : PTGIS (prostaglandin I2 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgis (prostaglandin I2 synthase)
Sus scrofa (pig) : PTGIS (prostaglandin I2 synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ptgis
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3438
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.